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Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder
- Bauer, M. (author)
- Glenn, T. (author)
- Achtyes, E. D. (author)
- show more...
- Alda, M. (author)
- Agaoglu, E. (author)
- Altinbas, K. (author)
- Andreassen, O. A. (author)
- Angelopoulos, E. (author)
- Ardau, R. (author)
- Aydin, M. (author)
- Ayhan, Y. (author)
- Baethge, C. (author)
- Bauer, R. (author)
- Baune, B. T. (author)
- Balaban, C. (author)
- Becerra-Palars, C. (author)
- Behere, A. P. (author)
- Behere, P. B. (author)
- Belete, H. (author)
- Belete, T. (author)
- Belizario, G. O. (author)
- Bellivier, F. (author)
- Belmaker, R. H. (author)
- Benedetti, F. (author)
- Berk, M. (author)
- Bersudsky, Y. (author)
- Bicakci, S. (author)
- Birabwa-Oketcho, H. (author)
- Bjella, T. D. (author)
- Brady, C. (author)
- Cabrera, J. (author)
- Cappucciati, M. (author)
- Castro, A. M. P. (author)
- Chen, W. L. (author)
- Cheung, E. Y. W. (author)
- Chiesa, S. (author)
- Crowe, M. (author)
- Cuomo, A. (author)
- Dallaspezia, S. (author)
- Del Zompo, M. (author)
- Desai, P. (author)
- Dodd, S. (author)
- Etain, B. (author)
- Fagiolini, A. (author)
- Fellendorf, F. T. (author)
- Ferensztajn-Rochowiak, E. (author)
- Fiedorowicz, J. G. (author)
- Fountoulakis, K. N. (author)
- Frye, M. A. (author)
- Geoffroy, P. A. (author)
- Gitlin, M. J. (author)
- Gonzalez-Pinto, A. (author)
- Gottlieb, J. F. (author)
- Grof, P. (author)
- Haarman, B. C. M. (author)
- Harima, H. (author)
- Hasse-Sousa, M. (author)
- Henry, C. (author)
- Hoffding, L. (author)
- Houenou, J. (author)
- Imbesi, M. (author)
- Isometsa, E. T. (author)
- Ivkovic, M. (author)
- Janno, S. (author)
- Johnsen, S. (author)
- Kapczinski, F. (author)
- Karakatsoulis, G. N. (author)
- Kessing, L. V. (author)
- Kim, S. J. (author)
- Konig, B. (author)
- Kot, T. L. (author)
- Koval, M. (author)
- Kunz, M. (author)
- Lafer, B. (author)
- Larsen, E. R. (author)
- Lenger, M. (author)
- Licht, R. W. (author)
- Lopez-Jaramillo, C. (author)
- MacKenzie, A. (author)
- Madsen, H. O. (author)
- Madsen, Saka (author)
- Mahadevan, J. (author)
- Mahardika, A. (author)
- Manchia, M. (author)
- Marsh, W. (author)
- Martinez-Cengotitabengoa, M. (author)
- Martini, J. (author)
- Martiny, K. (author)
- Mashima, Y. (author)
- McLoughlin, D. M. (author)
- Meesters, Y. (author)
- Melle, I. (author)
- Meza-Urzua, F. (author)
- Mikolas, P. (author)
- Mok, Y. M. (author)
- Monteith, S. (author)
- Moorthy, M. (author)
- Morken, G. (author)
- Mosca, E. (author)
- Mozzhegorov, A. A. (author)
- Munoz, R. (author)
- Mythri, S. V. (author)
- Nacef, F. (author)
- Nadella, R. K. (author)
- Nakanotani, T. (author)
- Nielsen, R. E. (author)
- O'Donovan, C. (author)
- Omrani, A. (author)
- Osher, Y. (author)
- Ouali, U. (author)
- Pantovic-Stefanovic, M. (author)
- Pariwatcharakul, P. (author)
- Petite, J. (author)
- Petzold, J. (author)
- Pfennig, A. (author)
- Ruiz, Y. P. (author)
- Pinna, M. (author)
- Pompili, M. (author)
- Porter, R. J. (author)
- Quiroz, D. (author)
- Rabelo-da-Ponte, F. D. (author)
- Ramesar, R. (author)
- Rasgon, N. (author)
- Ratta-apha, W. (author)
- Ratzenhofer, M. (author)
- Redahan, M. (author)
- Reddy, M. S. (author)
- Reif, A. (author)
- Reininghaus, E. Z. (author)
- Richards, J. G. (author)
- Ritter, P. (author)
- Rybakowski, J. K. (author)
- Sathyaputri, L. (author)
- Scippa, A. M. (author)
- Simhandl, C. (author)
- Smith, D. (author)
- Smith, J. (author)
- Stackhouse, P. W. (author)
- Stein, D. J. (author)
- Stilwell, K. (author)
- Strejilevich, S. (author)
- Su, K. P. (author)
- Subramaniam, M. (author)
- Sulaiman, A. H. (author)
- Suominen, K. (author)
- Tanra, A. J. (author)
- Tatebayashi, Y. (author)
- Teh, W. L. (author)
- Tondo, L. (author)
- Torrent, C. (author)
- Tuinstra, D. (author)
- Uchida, T. (author)
- Vaaler, A. E. (author)
- Vieta, E. (author)
- Viswanath, B. (author)
- Yoldi-Negrete, M. (author)
- Yalcinkaya, O. K. (author)
- Young, A. H. (author)
- Zgueb, Y. (author)
- Whybrow, P. C. (author)
- show less...
- (creator_code:org_t)
- 2023
- 2023
- English.
- In: International Journal of Bipolar Disorders. - 2194-7511. ; 11:1
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- BackgroundSunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample.MethodsData for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P <= 0.001.ResultsThe 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger.ConclusionUVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- vitamin-d
- circadian-rhythms
- sleep
- depression
- sunlight
- impact
- light
- Psychiatry
Publication and Content Type
- ref (subject category)
- art (subject category)
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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- and Psychiatry
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- University of Gothenburg
- Karolinska Institutet
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